Rand Simberg discusses the potential health hazards involved in a human pregnancy and birth in an environment at a fraction of earth’s gravity such as the 0.38g on Mars : The Bioethics of Mars One – PJ Media.
Before permanent settlements are the Moon and Mars are viable, he points to the need for a G-Lab orbital facility, which would use spin gravity to study the effects of fractional gravity on lab animals.
The NASA funded project HI-SEAS (Hawaii Space Exploration Analog and Simulation) is investigating human factor challenges for a Mars mission. They are starting with a four-month simulated mission with 6 non-astronaut “crew members” in a dome near Hawaii’s Mauna Loa volcano. One of the issues that will focus on is food, in particular those foods that can be stored for long voyages but are still tasty : Aloha, Mars! What we’ll eat, wear and play with to ease boredom in space – Cosmic Log
Here is a video from earlier this year when the project participants carried out a short term simulation at the Mars Society‘s Mars Desert Research Station in Utah:
The Russian Bion M1, launched on April 19, 2013 from the Baikonur Cosmodrome in Kazakhstan, and returned on May 19th. The biology mission appears to have been a mixed success: