From the caption:
Philosophers have long considered the possibility that we live in an artificial or simulated reality. Dr. Beane gives a short overview of some of the simulation arguments/scenarios that he personally finds most compelling.
Dr. Beane then attempts to frame the simulation argument in the context of science. In particular, discusses recent work which suggests various observational tests of the hypothesis that we are currently living in a simulated universe. These include studies of the cosmic microwave background, high-energy cosmic rays, and high-precision terrestrial experiments.